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2007 Dec 19;27(51):13997-4006

Appetite Effects The question about appetite is interesting because the proposed mechanism could reasonably go either direction: Reduced lipogenesis and improved metabolic flexibility could produce secondary effects on appetite regulation NAD+ restoration has complex effects on hypothalamic appetite signaling Preclinical data do not consistently describe dramatic appetite changes In human use were it to become clinically available patient-reported appetite effects would be a relevant monitoring parameter, but the data do not currently support a strong a priori expectation

doi:10.1042/bj0490481

Van De Veerdonk F, Netea MG, Van Deuren M, Van Der Meer JW, De Mast Q, Bruggemann RJ, et al