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Furthermore, the activation of FXR receptors inhibits the NF-B pathway, reduces the expression of the inflammatory factors TNF- and IL-1, and reduces intestinal inflammation 147

NOT TESTED ON ANIMALS

But the same property that makes it useful in culture is what makes any extrapolation to human physiology fraught: broad, persistent activation of a receptor that regulates growth, metabolism, and cell survival across virtually every tissue is a fundamentally different proposition from a self-limiting local pulse

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