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Further simulations showed that over a wide range of doxorubicin (050 M), the model can be used to suggest the specific concentration and exposure duration required to deplete cytosolic GSH by 70%, the threshold by which antioxidant defence is impaired, protein binding occurs, and cell death is possible

Fournier SB, DErrico JN, Adler DS, Kollontzi S, Goedken MJ, Fabris L, Yurkow EJ, Stapleton PA

doi: 10.1016/0378-4274(84)90065-1 5 ChenQ.GundlachM.YangS.JiangJ.VelkiM.YinD.et al

If you have any questions about this formulation or if more information is required, please do not hesitate to reach out to Bayview Pharmacy