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Upon perfusion, OPTEC tubules displayed proper polarization and expressed a broad array of proximal-tubule-specific functional markers, exhibiting higher expression levels of basolateral drug transporters, namely organic cationic/carnitine transporter 2 (OCT2), organic anion transporter 1 (OAT1) and OAT3, compared to immortalized PTECs

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Intense training with continuous rest deprivation increases the release of pro-inflammatory indicators, which may induce fatigue and overtraining syndrome in athletes [53]