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The thinking is that by concentrating the peptide in the inflamed or damaged areabe it the lower back near the compressed nerve root or the gluteal area for piriformis syndromeyou maximize its local effects before it enters systemic circulation

[DOI] [PubMed] [Google Scholar] 238.Pitzele H.Z., Tolia V.M

The levels of proinflammatory cytokines (such as IL-1, IL-6, IL-8, IL-12p40, IFN-, TNF- and GM-CSF) are increased, while those of anti-inflammatory cytokines (such as IL-10 and TGF-) are decreased, in the blood of ASD patients

He says the team plans to seek out more neurotransmitters, which might help bring them closer to identifying a viable therapy for those suffering from chronic back pain