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Microbiome differences were greater between the two groups switched from WD to LD (i.e., WD/LD-V and WD/LD-T) and the two diet control groups (i.e., LD/LD-V and WD/WD-V) compared to the microbiome differences observed between the lean (LD/LD-V) and obese (WD/WD-V) control groups

Histological analysis of epididymal fat revealed that Insr P1195L/ +/HFD mice had smaller adipocytes than those of WT/HFD mice, while there was no difference in adipocyte size between Insr P1195L/ +/ND and WT/ND mice (Fig

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