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APR-246 (PRIMA-1 met ) is the most clinically advanced mut-p53 targeting agent and has been shown to reactivate wt-p53 apoptotic functions 2

Vitamin D Prenatal vitamin D is essential for healthy bone development in the unborn child

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Several studies have shown an increased intestinal permeability in patients with liver cirrhosis.57 This may facilitate translocation of bacteria and bacterial products such as endotoxin into the systemic circulation,8 and thereby contribute to the development of cirrhotic complications, such as spontaneous bacterial peritonitis.9 Epithelial barrier function is regulated by intercellular tight junctions (TJ) and adherens junctions (AJ)