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In a research context exploring a very severe, acute, and localized muscle belly tear, some might argue for an IM protocol to study the effects of immediate, high-concentration saturation

Pharmacol Rev 43:109142 Nordt SP, Williams SR, Turchen S, Manoguerra A, Smith D, Clark RF (1996) Hypermagnesemia following an acute ingestion of Epsom salt in a patient with normal renal function

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Furthermore, a recent extensive cohort study involving over 33,000 GLP-1 RA users diagnosed with diabetes over a 9-year period indicated no significant increase in pancreatic cancer risk associated with GLP-1 RA use, as evidenced by an HR of 0.50 compared to basal insulin [60]