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The FDA metformin label lists iodinated contrast media as a major interaction requiring metformin discontinuation 48 hours before and after contrast administration due to acute kidney injury risk and potential lactic acidosis [6]

The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased

The reported effects are consistent across studies: accelerated wound healing, increased tensile strength, faster bone callus formation, and restoration of tissue architecture