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4 Integrating smoking-driven immunosenescence with MS course and progression The relationships among cigarette smoking, immunosenescence, and multiple sclerosis (MS) appear to converge on a common biological theme: a progressive shift from flexible, well-regulated immune responses toward chronically activated, less adaptable immune states

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PHE, 2018 Royal College of Physicians, Tobacco Advisory Group

Minnesota is also on its seventh ozone alert of the season -- the most alerts of its kind ever in the state