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REDEFINE 1 (Phase 3a, NEJM 2025) Garvey et al., n=3,417, 68 weeks

It must be handled using standard aseptic technique by qualified researchers in compliance with applicable EU regulations and institutional laboratory safety guidelines

Kannan, K., & Jain, S

These transgenerational effects operate primarily through epigenetic modifications, germline transmission of molecular alterations, and persistent fertility impairments that challenge traditional concepts of toxicological risk assessment (84)