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49 mtDNA point mutations and deletions increase exponentially with age, disrupt the assembly of the oxidative phosphorylation complex, reduce adenosine triphosphate (ATP) and increase electron leakage, and form a vicious cycle of ROS-damage-ROS

A 63-year-old woman presents for evaluation of compensated cirrhosis secondary to NASH

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Linear mixed effects models were also used to determine associations between the changes in metabolites and changes in HRSD 17 over time, with age and gender as covariates, and using subjects as random variable