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The global prevalence of MASLD increases in parallel with obesity rates, and a recent meta-analysis determined a prevalence of 75.27% in the obese population [5]

A recent investigation revealed that the expression of VRK2 was upregulated in response to ROS signals, while the link between VRK2 and metabolic rewiring remains obscure [18].In this study, we tried to explore the effects of VRK2 on the rewiring of metabolic networks and identify metabolic vulnerabilities resulting from VRK2-driven metabolic reprogramming