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As one of the most conserved structures in Gram-negative bacteria, LPS is recognized by the host to initiate potent immune responses against bacterial invasion

Use of the DFE reflects the higher bioavailability of synthetic folic acid found in supplements and fortified food compared to that of naturally occurring food folates (20)

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1,2 Although not clinically validated or available for widespread use, measurement of holotranscobalamin, the metabolically active form of vitamin B 12 , is an emerging method of detecting deficiency