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The expression levels of the mitochondrial fusion proteins MFN2 and OPA1 and the mitophagy-related protein p62 in obese patients is also significantly decreased, resulting in an imbalance in mitochondrial fusion, fission and clearance, which seriously affects mitochondrial quality [239,240,241]

Many studies have embraced microbiota-targeted intervention in modulating gut microbiota and their metabolites

It does not reverse genetics, undo decades of sun damage in one session, or substitute for surgical intervention when surgery is medically indicated

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