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GSH is mainly formed in the cytosol, however, GSSG is transported out of cells particularly when elevated possibly to maintain the high GSH/GSSG ratio although GSH is also transported out of liver cells possibly as a source of cysteine for other cells ( FIGURE 3 Induction of Changes in Intracellular ROS and Function in Response to Physiological Variations in Extracellular Redox Couples A redox communication system that shares information among metabolically sensitive tissues predicts that physiologically relevant changes in the putative redox indicator ratios will impact tissue ROS production and function

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Author contribution LE - developed the method, designed the study, performed measurements, analyzed the data, wrote the article

Levy, M