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In addition to its role in regulating gene expression through methyl-dependent epigenetic mechanisms, vitamin B12 is recognized for its neuroprotective, antioxidant, and anti-inflammatory properties 54

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showed that xCT knockout in two different PDAC cell lines (MIA PaCa-2 and CAPAN-2) induces ferroptosis and significantly affects growth and proliferation in vitro and in vivo when injected subcutaneously in nude mice (126)

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