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10.1038/nature04870 50 KarinM

Furthermore, the activation of AMPK by berberine directly phosphorylates and activates endothelial nitric oxide synthase (eNOS), the enzyme responsible for producing the vasodilating molecule nitric oxide (NO)

Despite preliminary findings, the clinical efficacy and safety of these interventions in PD in these earlier studies remain inconclusive, with variability in reported outcomes

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