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The authors attributed this to the possible presence of divalent ions (Calcium (II), Strontium (II), and Barium (II) ions) or quercetin-like compounds which are reported to augment the activity of phospholipase A 2 through induction of conformational changes in its substrate-binding sites [167, 168]

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In fact, consuming NNK and NNAL (0.5, 1 and 5ppm) in drinking water for a lifetime by rats did not induce pancreatic ductal adenocarcinoma, except in 13% of rats treated with the high dose of 5ppm of NNAL (90)