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Description

Estrogen deficiency and the decline of skin collagen were first observed in 1941 by Albright, who noticed that thin skin was more common in older women with osteoporotic fractures [21]

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Copper complexation is performed by mixing the purified tripeptide with copper(II) salts (chloride, acetate, or sulfate, depending on the protocol) at controlled pH, with the resulting complex purified by chromatography

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