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The observation of significantly lower levels of creatine in patients with Long COVID implies the potential impairment of this essential homeostatic pathway

Kremer et al., 2024) with an indispensable role of STAT3 activation due to methylation at a CpG site in the GFAP promoter (Takizawa et al., 2001), and in TET1/2/3-mediated DNA demethylation for establishing neural stem cell identity and enabling glial (e.g., astrocyte and oligodendrocyte) differentiation (MacArthur et al., 2024)

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This assumption was verified in a follow-up study that activation of anti-viral responses by polyinosinic-polycytidylic acid attenuated APAP-induced hepatotoxicity through transcriptional down regulation of RXR and PXR and their downstream CYPs [34]