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Furthermore, iron-regulatory proteins (IRPs), comprising IRP1and IRP2, regulated the expression of TF, TFR1, DMT1, and FPN1 by binding to a stem-loop structure located in the 3- or 5-untranslated region of the target mRNA for stabilization (Wang and Pantopoulos, 2011)

Also, if there are low levels of cysteine in cells during times of oxidative stress, this may limit their ability to make their own glutathione

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& Jeggo, P