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It is also important to note that the increase in efficacy of the drug regimen did not correlate with any increase in toxicity to healthy tissues (Murphy 2011)

Further examination of immune responses from biopsy samples might provide useful information in elucidating the IBS pathophysiology and identify any potential disease indicators ( Gut Motility Changes Patients with IBS often have changes in their gut motility, which is usually driven and augmented by stress via gut-brain axis ( Dietary Influence Diet plays a crucial role in IBS pathogenesis through modulating the normal gut microenvironment including decrease in colonic fermentation, altered gut microbiome composition and reduced antigen activation by the gut immune system (Muegge et al., 2011