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Abstract Purpose: In this research the effect of vitamin B 1 and B 6 on cyanocobalamin stability in commercial light protected parenteral formulations and upon adding stabilizing agents will be investigated and best formulation composition and proper storage condition will be introduced

Key diagnostic elements include: Cyclical symptom pattern: Skin symptoms recur in a predictable, monthly patternmost often flaring 57 days before menstruation and improving rapidly with the onset of menses, when progesterone levels fall

Whatever the cause of the deficiency is, oral and injection supplements are considered safe and viable to treat the issue