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A Phase IIb trial of mRNA-4157 in combination with pembrolizumab for patients with resected high-risk melanoma showed that this combination therapy prolonged recurrence-free survival compared with pembrolizumab monotherapy and had a manageable safety profile

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Importantly however, RSL3-containing combinations displayed growth control even after drug washout, with the triple combination being most effective and independent of the pre-treatment regime, consistent with having a cell lethal effect (Fig

Modern medicine uses synthesized versions of these molecules to treat metabolic diseases, genetic disorders, and bacterial infections