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In macrophages, reorganization of the actin cytoskeleton necessary for chemotaxis and phagocytosis requires MsrB1-dependent reduction of methionine-R-sulfoxide residues within actin (27)

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A number of antitumor agents, including vinblastine, cisplatin, doxorubicin, camptothecin and several others have exhibited antitumor activity via the ROS-dependent activation of apoptotic cell death, suggesting the potential use of ROS as an antitumor agent (16)