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In addition, respiratory and gastrointestinal epithelia have structural similarities, having the same embryonic origin (Figure 1)

Acetaldehyde can irritate the lining of your lungs and throat, leading to coughing, a sore throat, and an overall feeling of discomfort

Addiction 115:11411148 Jacob P III, Yu L, Duan M, Ramos L, Yturralde O, Benowitz NL (2011) Determination of the nicotine metabolites cotinine and trans-3-hydroxycotinine in biologic fluids of smokers and non-smokers using liquid chromatographytandem mass spectrometry: biomarkers for tobacco smoke exposure and for phenotyping cytochrome P450 2A6 activity

Its what keeps smokers smoking and ingesting all the other toxins in cigarette smoke