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A single fat source alone may not be enough to alter BA production in humans, as consumption of virgin olive oil with or without thyme did not alter BA production when volunteers were asked to limit their polyphenol-rich food intake ( 5.3 TMAO and its dietary precursors TMAO is a product of choline, L-carnitine, betaine, and ergothioneine via metabolism by the gut microbiota

Beyond these factors, an inherent consideration in Bispecific targeting is the potential requirement for co-expression of both target antigens on the same tumor cell for optimal activity

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