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At week 24, mean body weight reduction at the 12 mg amount was approximately 16.9%, with concentration-dependent reductions in HbA 1c across all retatrutide arms compared with placebo and dulaglutide

The Broad Institute CMap provides powerful data but uses specific cell lines and conditions that may not perfectly represent all tissue types

The transcriptomic approach was done under these two conditions so that we would obtain an unbiased insight into (a) the possible pathways or proteins that were targets of 5-OP leading to their inactivation and consequently the effect on growth and (b) the cellular response to 5-OP toxicity enabling the cells to tackle the 5-OP treatment and accumulation

Dymek, K