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& Parkes, D

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These mechanisms mirror those of other IGF-1 forms but occur with higher local intensity due to IGF-1 DES's enhanced potency

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These are in accordance with the effects noted in the esophagocutaneous fistulas- or hyperkalemia-sphincter dysfunction (10, 25) and the obtained sphincters interrelation (i.e., the failure of the pyloric sphincter induced the failure of the lower esophageal sphincter (41-43))

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[3] The therapeutic window depends entirely on getting the ratio of GCGR-to-GLP-1R activity right too much glucagon signaling relative to GLP-1 could worsen glucose control

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