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At the onset of the psoriatic cascade, interferon- has a role in promoting the production of CCL20, IL-17 + T cells, and -defensin2 (HBD-2), which is a protein that is both antimicrobial and chemotactic in nature

Most protocols suggest: 46 weeks on 13 weeks off before resuming if needed This cycling approach allows healing to continue naturally and may preserve long-term peptide sensitivity

Int J Med Mushrooms 19(2):179189 Zheng H, Kim J, Liew M, Yan JK, Herrera O, Bok JW, Kelleher NL, Keller NP, Wang Y (2015) Redox metabolites signal polymicrobial biofilm development via the NapA oxidative stress cascade in Aspergillus

Science 323, 101106 (2009)