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For patients with confirmed pernicious anaemia or malabsorption disorders, injectable therapy remains the recommended first-line treatment according to NICE CKS guidance, as oral supplementationregardless of dosecannot reliably correct deficiency in these circumstances

84 Another study found higher intakes of folate and vitamin B12 were both associated with lower homocysteine levels and better sperm parameters in men with MTHFR polymorphisms

For those with deficiencies or certain health conditions that impede nutrient absorption from food sources alonesuch as pernicious anemia or gastrointestinal disordersa direct injection can be life-changing

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