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However, the oral route cannot be excluded as it did not depend on intrinsic factors only, as the simple diffusion (without the need for intrinsic factors) is now considered another mechanism for the absorption of vitamin B12 [49, 50]

Some research has shown that even in the absence of functional beta-3 receptors, acute AOD-9604 administration still increased energy expenditure and fat oxidation, suggesting the peptide may influence brown fat or thermogenic pathways through additional mechanisms