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and (3) pain defined as distal extremity pain plus one of the following: dysesthesia, burning/painful feet worsening at night or intolerance of sheets/clothes touching the legs or feet

LL-37's diverse roles in immunity and host defense warrant further research to unravel its precise mechanisms of action and potential applications in clinical medicine

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In addition to the NF-B pathway, the mitogen-activated protein kinase (MAPK) signaling cascade is also an important regulator of inflammatory responses in CNS microglia