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The meta-analysis of Wang et al

Pregnancy and lactation A retrospective observational study reported that daily oral supplementation with 600 mg of lipoic acid (racemic mixture) during pregnancy and without interruption from a period spanning between week 10 and week 30 of gestation and until the end of week 37 was not associated with any adverse effect in mothers and their newborns (114)

Thats when oxidative stress builds up and starts causing damage at a deeper level

However, this effect may be due to the large amount of cystine provided in the control conditions (208 M), as reduction of cystine levels in the medium did not impair growth but abolished intracellular cysteine and cystine levels (Extended Data Fig