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The more reduced mitochondrial [NAD + ]/[NADH] during fasting and DR from increased neural fatty acid oxidation (low capacity in neurons) and ketone body oxidation may slow the mitochondrial malate dehydrogenase 2 (MDH2) enzyme of the MAS, inhibiting flux through the MAS leading to the more reduced cytoplasmic [NAD + ]/[NADH] observed in the brain of animals on the DR diet

Hydroxychloroquine (HCQ), which is known for its immunoregulatory, anti-inflammatory, antiproliferative, and anti-photoallergic properties, is commonly used to treat SLE (96, 97)

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