Undeveloped embryonic and fetal defense systems are unable to counteract an overload of OS without support from exogenous antioxidants [282]
So, graying may start after about ten hair cycles, when pigment deposition declines as the pigment generating cells, called melanocytes, start to become depleted
The integration of these signalling pathways regulates various developmental processes, including proliferation, differentiation, fate determination, apoptosis, migration, adhesion, and cell shape, ultimately impacting organogenesis
Clin J Am Soc Nephrol 6:3039 Wautier MP, Chappey O, Corda S, Stern DM, Schmidt AM, Wautier JL (2001) Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE