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Recently, the obvious senescence phenotypes in keloid lesions and fibroblasts were found and senolytic dasatinib was demonstrated to have antifibrotic effects in keloids 14,15

These findings should be overseen with glutamate as the major excitatory neurotransmitter in the central nervous system (i.e., cognitive functions such as learning and memory in the brain [200], the precursor of major inhibitory neurotransmitter GABA) but excitotoxic neuronal death as a direct result of high concentrations [201], and tight physiologic range that should be maintained [59]

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