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Potential NAC Side Effects For most people, oral NAC is safe and well-tolerated, meaning it's unlikely to cause side effects and is an FDA-approved supplement 42

In addition to the VHL-HIF-VEGF/vascular endothelial growth factor receptor (VEGFR) pathway, VHL mutations affect signaling regulation in the mTOR and epidermal growth factor receptor (EGFR) pathways, promoting tumor growth (130)