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Because DSIP influences the central nervous system and the bodys stress response / hormonal balance (for example via modulation of growth hormone, circadian rhythms, emotional and psychological responses) users should approach with caution, ideally under experienced oversight if in research or specialty wellness settings

Cheng WH, Ho YS, Ross DA, Valentine BA, Combs GF Jr, Lei XG

The expanded null cell compartment in ageing: increase in the number of natural killer cells and changes in T-cell and NK-cell subsets in human blood

In many cases, what appears to be a reaction may simply be localized fluid placement within the dermal layer