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En estudios de cultivo celular, el tratamiento con Epithalon activa la telomerasa en fibroblastos fetales humanos, extendiendo su vida replicativa ms all del lmite de Hayflick normal el nmero mximo de veces que una clula humana normal puede dividirse

IGF-1 is necessary for MSC differentiation, not recruitment during bone remodeling To examine the mechanism of the reduced bone mass in the MSC- Igf1r / mice, we performed immunohistochemical staining for Osterix and Osteocalcin to label osteoprogenitors and mature osteoblasts, respectively in mouse femora