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[166] [167] Symptoms In a 2007 review of the effects of abstinence from tobacco, Hughes concluded that anger, anxiety, depression, difficulty concentrating, impatience, insomnia, and restlessness are valid withdrawal symptoms that peak within the first week and last 24 weeks. [169] In contrast, constipation, cough, dizziness, increased dreaming, and mouth ulcers may or may not be symptoms of withdrawal, while drowsiness, fatigue, and certain physical symptoms (dry mouth, flu symptoms, headaches, heart racing, skin rash, sweating, tremor) were not symptoms of withdrawal

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