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7.3 Hepatic oxidative stress and the protective role of Nrf2 signaling A key aspect highlighted in this review is the central role of the Nrf2-Keap1-ARE signaling pathway as a major regulator of the hepatic antioxidant response

To address the heterogeneity of the included studies, we opted for a structured synthesis based on target populations (e.g., MCI, SCD, mixed samples) and outcome domains (e.g., cognitive, motor, usability)

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