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Any physician or clinic prescribing these substances outside of a formal, FDA-sanctioned clinical trial is operating outside the standard of care

Smith MH, Ploegh HL, Weissman JS (2011) Road to ruin: targeting proteins for degradation in the endoplasmic reticulum

3 Immunohistochemistry of interleukin-1 (IL-1) in the dorsal root ganglion (DRG) and spinal cord (SC) at (A) 5 min (representative value of phase 1) and (B) 35 min (representative value of phase 2) Graph (bottom) represents the number of immunostained cells in the DRG and SC (mean SD)