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We observed that SFN treatment led to a significant decrease in both STIM2, Orai1, and Orai3 expressions (Figures 6A,B)

Ames: Wiley-Blackwell

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The epithelium of the non-inflamed ileum shows a normal permeability to ions and a normal paracellular permeability to 51 Cr-EDTA as compared to controls (119, 120) but is more susceptible to a challenge with sodium caprate indicating that TJs in the non-inflamed ileum of CD are more reactive to luminal stimuli contributing to the development of mucosal inflammation (120)