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However, a second generation of e-cigarettes evolved with functionality and design changes that allowed higher nicotine delivery, though still lower than combustible cigarettes [13]

[2] LD was introduced in North Carolina and South Carolina to act as a test market, with plans to expand if successful

While the association was strongest for traditional smokers, the study noted that vaping alone may still carry cardiovascular risks, although the smaller number of exclusive vapers in the sample limited statistical certainty

[4] Some rely on gravity to bring the e-liquid to the wick and coil assembly (bottom coil clearomizers for example) and others rely on capillary action or to some degree the user agitating the e-liquid while handling the clearomizer (top coil clearomizers)