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Neuroimaging studies show reduced volume in the frontal lobes, striatum, and interconnecting white matter in individuals with ADHD, which may be attributed to delayed cortical maturation (145, 146)

Dead volume accounting Every vial has dead volume, the small amount of solution trapped below the needle tip when the vial appears empty

Once the tumour became arrested in the palbociclib-treated group, mice were further randomized to receive either RSL3 (50 mg kg 1 , two times per week for 2 weeks) or the vehicle, resulting in four experimental groups: vehicle, RSL3, palbociclib and palbociclib + RSL3