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The first instar larvae taken 24 h AEL (after egg laying), was orally administered with 2.5 mM Sp and fluorescence measurement in brains of eclosed adults were performed as mentioned above

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The primary evidence-based interventions remain: Weight loss through caloric restriction and increased physical activity (target 710% body weight reduction) Dietary modification , including reduced sugar and saturated fat intake Management of associated conditions such as diabetes and dyslipidaemia Alcohol : for NAFLD, keep within UK low-risk drinking guidelines (no more than 14 units per week, ideally less or none)