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Juvenility of tobacco induced by cytokinin gene introduction decreases susceptibility to Tobacco necrosis virus and confers tolerance to oxidative stress

Kim HB, Kim YJ, Lee YJ, Yoo JY, Choi Y, Kim EM, Suh SW, Woo RS (2024) N-Acetylcysteine alleviates depressive-like behaviors in adolescent EAAC1(-/-) mice and early life stress model rats

Substances that are absorbed through the buccal route go directly into the systemic circulation and this eliminates disadvantages imposed by oral intake, such as the decreased ability of GSH to pass through the gastrointestinal tract as an intact molecule

Due to this dysfunction, there is an increase in the levels of glutamate in the synaptic cleft that activates the glutamate receptors which are present in the post-synaptic neurons (N-Methyl-D-aspartic acid (NMDA), -amino-3-hidroxi-5-methyl-4-isoxazolpropionic acid (AMPA), Kainate, and metabotropic glutamate (mGLUR) receptors), leading to excitotoxicity