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Erdman J, Oria M, Pillsbury L, editors

Introduction HIV-associated neurocognitive disorder (HAND), encountered in up to 50% of HIV patients, is characterized by cognitive deficits that may occur despite adequate treatment with combination antiretroviral therapy (cART) ( Viruses require iron for replication and often obtain this nutrient by targeting the iron-rich organelles, mitochondria, and lysosomes, disrupting their function, including ferritinophagy and myelination ( Ferroptosis is a programmed cell death triggered by iron-mediated lipid peroxidation in the absence of antioxidants glutathione (GSH) or glutathione peroxidase 4 (GPX4)